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A new polymer-based approach for in vivo transfection in postnatal brain

A new polymer-based approach for in vivo transfection in postnatal brain
use of BrainFectIN for in vivo gene silencing using shRNA encoding plasmids in mouse brain

 

"A new polymer-based approach for in vivo transfection in postnatal brain"
Di Scala C. et al, Journal of Neuroscience Methods, 2018

 

Abstract

"Gene delivery within the central nervous system at postnatal age is one of the most challenging tasks in neuroscience and currently only a few effective methods are available. [...] We describe a new polymer-based gene delivery system allowing persistent and robust in vivo transfection with low DNA amount, reduced inflammation and high diffusion."
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BrainFectIN™ is an original non-viral formulation that allows safe, easy and efficient nucleic acids delivery into central nervous system of small animals.
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Discover our other solutions for neuroscience applications:

 

- Glial-Mag reagent for Glial cells transfection
"Magnetofection is superior to other chemical transfection methods in a microglial cell line"
Smolders S. et al, Journal of Neuroscience Methods, 2017

 

- Neuromag dedicated to neurons transfection
"Achieve up to 30% of transfection efficiency on primary cortical neurons."
Wang R et al, Neurobiol Dis. 2014