Highly Potent Non-Viral Drug Delivery Nanosystems

The Need of Advanced Delivery Systems

The RNA therapeutics have the potential to revolutionize medicinal fields as they are safe, easy to reproduce (e.g. IVT) and offer a great deal of versatility.

Naked mRNA therapeutics are generally unstable. They require high doses and show low permeability to cell membranes. Drug delivery systems are necessary to deliver mRNA for in vitro, pre-clinical and clinical applications. For this purpose, OZ Biosciences provides portfoliocustom lipid nanoparticles (LNP) delivery systems.

To date, formulation in LNP represents the most advanced non-viral delivery platform for nucleic acid therapy and promising candidates to treat manifold diseases..

LNPs were FDA approved for the treatment of amyloidosis disease by delivery of siRNA (e.g. Patisiran), and more recently for the widely distributed SARS-CoV-2 vaccines (e.g. BNT162b2 and mRNA-1273), based on mRNA-LNPs.

Therefore, LNPs represent an efficient approach to deliver:

  • Nucleic Acid Payloads (DNA and RNA) and/or
  • Active Pharmaceutical Ingredients (APIs) such as small drugs or proteins into the cells. 

NanOZ-LNPs Offers A Potent Candidate For Nucleic Acids/APIs Medicines

About NanOZ-LNPs 

LNPs are liposome-like structures, engineered for encapsulating a broad variety of nucleic acids (RNA, mRNA, siRNA, gRNA, cRNA and DNA) and APIs; LNPs consist in an aqueous core surrounded by a lipidic shell based on a combination of 4 families of chemicals, each having distinct functions (Fig.2). 

Lipid NanoParticles

Figure 1. Schematic representation of lipid nanoparticles (LNPs) composed by a mixture of four lipidic family, usually: complexing lipid, helper phospholipid, cholesterol and stealth-lipid at defined ratio to potentiate nucleic acid activity.

In the last 20 years, OZ Biosciences has developed strong expertise in aminated lipids, which allowed the screening of several tens formulations in order to develop optimized OZ Biosciences LNPs referred as NanOZ-LNP.

NanOZ-LNP have been designed as safe and advanced nanomaterials to potentiate nucleic acids/APIs activity through their effective encapsulation and delivery of payload to specific cell types and tissues.

OZ Biosciences LNP Custom Service

OZ Biosciences has developed a Microfluidics Platform for the reproducible development of safe & potent drug delivery vehicles for pharmaceutical applications.

We can support every stage of your mRNA-LNP production, from mRNA synthesis to LNP formulation development, manufacturing and fill & finish.

For any of RNA, DNA or APIs encapsulation, you can provide us with your molecule of interest and we will formulate it into LNPs.