Blog
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Activity-dependent 5′tRF GluCTC modulates neuronal networks in hiPSC neurons
Published : 10/07/2026Authors: Stewart, R. et al. Source: Cell Death Dis. They investigated the activity-dependent generation and extracellular release of 5′tRF GluCTC in hiPSC-derived cortical neurons...
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Small-Molecule-Mediated Depletion of the DYRK1B Protein Scaffold
Published : 09/30/2026Authors: Miriam Ems, et al. Source: ACS Pharmacol. Transl. Sci. They identified LCTB-92, a small molecule from the leucettinib class of DYRK inhibitors...
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LNP-mediated mRNA delivery in human PBMC: T cell-targeted transfection
Published : 09/24/2026Application note: transfection efficiency, cell-type tropism and viability of a new ionizable lipid LNP formulation in human PBMCs, with focus on T cells.
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Geneformer-guided multiomics identifies Pbx1 as a network hub of HSC aging
Published : 09/16/2026Authors: Hiroshi Kobayashi et al. Source: Science Advances. They integrated deep learning foundation models with transcriptomic and epigenetic profiling to...
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Our cationic poloxamers patent is now granted in Australia
Published : 09/09/2026Patent No. AU2020314617, “CATIONIC POLOXAMERS AND THEIR USE IN TRANSDUCTION,” covers our method for synthetically modifying poloxamers to confer additional biological properties...
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Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia
Published : 09/02/2026Authors: Medina-Guzmán, R., et al. Source: Cell Death Dis. They showed that basal caspase-3 activity regulates RNA splicing in microglia, and its deficiency in a Parkinson's disease...
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How Magnetofection unlocks high-efficiency CRISPR Genome Editing
Published : 08/25/2026Paper from: Go I, Lee SH. Front Genome Ed. A controlled, head-to-head benchmark of PolyMag Neo magnetofection against lipofection across Cas9, Cas12, prime editing and RNP delivery.
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HIV-1-specific CAR-T cell activity enhanced by IL-15 and TGF-β modulation
Published : 08/19/2026Authors: Lamcaj S et al. Source: Journal of Virology. They demonstrated that HCW9218, a bifunctional immunomodulatory protein composed of TGF-βRII...