Blog
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Multiple LDLR family members act as entry receptors for yellow fever virus
Published : 11/26/2025Authors: Chong, Z., Hui, S., Qiu, X. et al. Source: Nature (2025). "They conducted a pivotal study using a CRISPR–Cas9 screen to clarify the long-unanswered
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New ready-to-use LNP-siRNA for efficient gene silencing
Published : 11/19/2025Designed based on our expertise in lipid nanoparticle engineering, these ready-to-use LNPs ensure siRNA protection, enhanced intracellular uptake, and robust knockdown efficacy.
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ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration
Published : 11/12/2025Authors: Qiwang Xiang et al. Source: Sci. Adv. They identified the E3 ubiquitin-protein ligase ITCH as a critical driver of Golgi fragmentation, a recognized...
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Human CD4 T cells are functional targets for LNP-based mRNA vaccines
Published : 11/06/2025Authors: Kim SC, et al. Source: mBio. They discovered that CD4 T cells are an unexpected and dominant target for lipid nanoparticle (LNP) transfection...
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Aurora Kinase A inhibition favors CRISPR/Cas9 gene correction over knock-out
Published : 10/29/2025Authors: Wilbie D, Eising S, Amo-Addae V, Walther J, Bosman E, et al. Source: PLOS ONE 20(9): e0332617. They screened a library of oncological drug compounds to steer the DNA repair...
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PolyMag Premium™ is now available!
Published : 10/22/2025PolyMag Premium™ is a new magnetic nanoparticle formulation specifically designed to achieve high transfection efficiency in a wide variety of primary and hard-to-transfect cells.
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Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells
Published : 10/15/2025Authors: M. M. Trines, D. Hoorn, S. R. Hofstraat, et al. Source: Adv. Mater. (2025). They designed a series of polyvalent ionizable cationic dendrimers and incorporated...
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The adaptor SKT interacts with PSD-95 and SHANK3 and affects synaptic functions
Published : 10/08/2025Authors: Morellato, Alessandro et al. Source: Cell Reports. They identified the adaptor protein SKT as a crucial component of the postsynaptic density (PSD) network...