Blog
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Aberrant phase separation of two PKA RIβ neurological disorder mutants
Published : 07/16/2025Authors: Pool, Emily H. et al. Source: Cell Reports. "Spatiotemporal regulation of key-node signaling molecules, such as 3′,5′-cyclic adenosine monophosphate...
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BCL2 drives castration resistance in castration-sensitive prostate cancer
Published : 07/10/2025Authors: Hirani, Rahim et al. Source: Cell Reports. "Progression following androgen-deprivation therapy (ADT) and the development of castration resistance...
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The transcritption factors mRNA range is expanding!
Published : 07/02/2025We are pleased to announce an addition to the transcription factor mRNA category : KLF4, Nanog, Lin28 & OCT4 mRNA.
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Lipid Nanoparticle Development for Bivalent mRNA Vaccine
Published : 06/25/2025Authors: Jiin Felgner et al. Source: npj Vaccines. "mRNA vaccines represent a promising alternative to conventional vaccines, as demonstrated by the rapid deployment of mRNA vaccines...
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T cell receptor mimic CAR T cells targeting cathepsin G signal peptide
Published : 06/18/2025Authors: Yan, J. et al. Source: Leukemia. "There has been a been a paucity of immunotherapy targets in myeloid malignancies. We identified the HLA-A2 (A2)...
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HYPE-293 is now available in Superior Grade quality control
Published : 06/11/2025We're pleased to announce the development of a new HYPE-293 Superior Grade. Identic to HYPE-293 with extensive quality controls for preclinical trial use.
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Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution
Published : 06/04/2025Authors: Shunji Abe et al. Source: Journal of Controlled Release. "With the approval of mRNA vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lipid nanoparticles (LNP)...
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siNPAIN project: bi-annual progress meeting at i3S, in Porto
Published : 05/27/2025We're now at month 36 of this 54-month European project, and we’re proud to lead Work Package 1.