NanOZ LNP-mRNA

NanOZ LNP-mRNA are ready-to-use lipid nanoparticles (LNPs) loaded with messenger RNA (mRNA).

OZ Biosciences mRNAs resemble fully mature mRNAs, with a 5' Cap1 structure and a 3' poly(A) tail, and are ready to be translated by the ribosome. mRNA is non-integrative: unlike plasmid DNA, it cannot lead to genetic insertion causing mutations. Protein expression from mRNA is promoter-independent and faster than from DNA, which makes mRNA relevant for stem cell research, regenerative medicine and vaccine studies. mRNA can also be used as a control of transfection efficiency.

NanOZ LNPs are lipidic spherical vesicles formed by four main components: ionizable cationic lipid, helper phospholipid, cholesterol and pegylated lipid, each having a distinct function. The saRNA self-assembles with the ionizable cationic lipid through electrostatic interactions. Formulation by microfluidic technology results in monodisperse LNPs with a narrow size distribution and an encapsulation efficiency >80%.

The range covers in vitro transfection (NanOZ LNP in vitro), in vivo delivery with organ-selective biodistribution (NanOZ LNP Liver, Spleen and Multi-Organ), immunization (NanOZ LNP Immunization) and stem cells (NanOZ LNP Stem Cells). GFP, FLuc and OVA mRNAs are also available in LNPs formulated with the ionizable lipid SM-102.

For custom LNP formulations, you can request a quote by filling in our dedicated form.