Circular RNA (circRNA)

OZ Biosciences' circular RNAs (circRNAs) are ready-to-use, covalently closed, single-stranded RNA molecules produced by in vitro transcription followed by ribozyme-mediated circularization, with translation initiated through an internal ribosome entry site (IRES). Lacking free 5' and 3' ends, circRNAs are protected from exonuclease-mediated degradation, and extended protein expression compared with linear mRNA has been reported (1, 2).

The range currently includes eGFP circRNA, a reporter to assess transfection efficiency by fluorescence.

(1) Wesselhoeft RA et al. Nat Commun. 2018;9:2629. doi:10.1038/s41467-018-05096-6

(2) Shen Y et al. Nat Commun. 2025;16:7376. doi:10.1038/s41467-025-62607-y