Blog
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Lipid Nanoparticle Development for Bivalent mRNA Vaccine
Published : 06/25/2025Authors: Jiin Felgner et al. Source: npj Vaccines. "mRNA vaccines represent a promising alternative to conventional vaccines, as demonstrated by the rapid deployment of mRNA vaccines...
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T cell receptor mimic CAR T cells targeting cathepsin G signal peptide
Published : 06/18/2025Authors: Yan, J. et al. Source: Leukemia. "There has been a been a paucity of immunotherapy targets in myeloid malignancies. We identified the HLA-A2 (A2)...
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Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution
Published : 06/04/2025Authors: Shunji Abe et al. Source: Journal of Controlled Release. "With the approval of mRNA vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lipid nanoparticles (LNP)...
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Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction
Published : 05/09/2025Authors: Xiuhong Ye et al. Source: Adv. Sci. 2025. "Antisense oligonucleotide (ASO) therapy holds promise in gene therapy but faces challenges due to poor delivery efficiency...
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Oligomerised RIPK1 is the main core component of the CD95 necrosome
Published : 04/30/2025Authors: Nikita V Ivanisenko et al. Source: EMBO J (2025). "The necrosome is the key macromolecular signaling platform initiating necroptosis...
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Circulating miRNAs are associated with successful bone regeneration
Published : 04/16/2025Authors: Frank Julia K. et al. Source: Frontiers in Bioengineering and Biotechnology. "Bone healing is a well-orchestrated process involving various bone cells...
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TREK-1 in regulating adipocyte differentiation and lipid accumulation
Published : 04/10/2025Authors: Kim, A., Jung, S., Kim, Y. et al. Source: Cell Death Dis 16, 164 (2025). "K2P (two-pore domain potassium) channels, a diversified class...
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Variability in proliferative and migratory defects in Hirschsprung disease
Published : 04/03/2025Authors: Fries, Lauren E. et al. Source: Cell Pres - AJHG. "Hirschsprung disease (HSCR) exhibits extensive genetic heterogeneity, with 72% of cases...