Blog
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NGF cmRNA-engineered stem cells induce functional neurite outgrowth
Published : 11/04/2026Paper from Polain et al. showing NGF cmRNA-transfected hMSCs induce neurite outgrowth in vitro within the EU-funded cmRNAbone bone repair project.
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TBK1 eliminates monomeric TDP-43 via an IFNβ-immunoproteasome pathway in ALS
Published : 10/28/2026Authors: Sakai, S. et al. Source: EMBO Reports. "They identified a TBK1-IFNβ-immunoproteasome axis as a novel autophagy-independent proteostatic pathway regulating TDP-43 clearance...
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Activity-dependent 5′tRF GluCTC modulates neuronal networks in hiPSC neurons
Published : 10/07/2026Authors: Stewart, R. et al. Source: Cell Death Dis. They investigated the activity-dependent generation and extracellular release of 5′tRF GluCTC in hiPSC-derived cortical neurons...
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Small-Molecule-Mediated Depletion of the DYRK1B Protein Scaffold
Published : 09/30/2026Authors: Miriam Ems, et al. Source: ACS Pharmacol. Transl. Sci. They identified LCTB-92, a small molecule from the leucettinib class of DYRK inhibitors...
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Geneformer-guided multiomics identifies Pbx1 as a network hub of HSC aging
Published : 09/16/2026Authors: Hiroshi Kobayashi et al. Source: Science Advances. They integrated deep learning foundation models with transcriptomic and epigenetic profiling to...
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Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia
Published : 09/02/2026Authors: Medina-Guzmán, R., et al. Source: Cell Death Dis. They showed that basal caspase-3 activity regulates RNA splicing in microglia, and its deficiency in a Parkinson's disease...
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How Magnetofection unlocks high-efficiency CRISPR Genome Editing
Published : 08/25/2026Paper from: Go I, Lee SH. Front Genome Ed. A controlled, head-to-head benchmark of PolyMag Neo magnetofection against lipofection across Cas9, Cas12, prime editing and RNP delivery.
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HIV-1-specific CAR-T cell activity enhanced by IL-15 and TGF-β modulation
Published : 08/19/2026Authors: Lamcaj S et al. Source: Journal of Virology. They demonstrated that HCW9218, a bifunctional immunomodulatory protein composed of TGF-βRII...