Blog
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AMBRA1 enhances Sonic Hedgehog signaling in cerebellum and medulloblastoma
Published : 05/06/2026Authors: Irene Basili et al. Source: Developmental Cell. "They identified AMBRA1 as a key-tumorigenic factor that drives the Sonic Hedgehog subtype..."
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Cytokine-fusion scaffold generates CAR T cells enriched in long-lived TSCM
Published : 04/30/2026Authors: Erin B. Cole et al. Source: Sci. Adv. This study demonstrates that replacing conventional aCD3/28 activation with HCW9206 cytokine scaffold generates CAR T cells...
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Transdermal Delivery of an mRNA-Liposome Vaccine via Dissolving Microneedle
Published : 04/16/2026Authors: J.Nam, J.Ahn, J.Shin, et al. Source: Advanced Science (2026). They developed an innovative multilayer dissolving microneedle platform (ML-DMN)...
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Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype
Published : 04/01/2026Authors: Cheray, M., Posada-Pérez, M., Fragkopoulou, A. et al. Source: Cell Death Differ (2026). They discovered that a transient reduction in DNA methylation...
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CRISPR-based functional genomics in primary acute myeloid leukemia samples
Published : 03/25/2026Authors: Cao Z, Yu S, Peng J et al. Source: Molecular Cell. They developed an optimized CRISPR-based platform for functional genomics in patient-derived xenograft (PDX)...
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Enhancing transduction efficiency of lentiviral vectors in CAR-T cell therapy
Published : 03/19/2026Authors: Ferreira R et al. Source: Front. Med. The stepwise optimization developed in this study brought transduction efficiency of the anti-FITC-CAR construct from an average of ~1% to ~50%
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An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein
Published : 03/11/2026Authors: Feng Han et al. Source: mBio. They identified a novel antiviral target on the HPV18 E7 oncoprotein and demonstrated...
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Discovery of a selective ERAP1 inhibitor for Hedgehog-dependent cancer treatment
Published : 02/26/2026Authors: Bufalieri, Francesca et al. Source: Molecular Therapy. They identified Canthin-6-one (N1) as a selective inhibitor of ERAP1...