Blog
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Human CD4 T cells are functional targets for LNP-based mRNA vaccines
Published : 11/06/2025Authors: Kim SC, et al. Source: mBio. They discovered that CD4 T cells are an unexpected and dominant target for lipid nanoparticle (LNP) transfection...
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Aurora Kinase A inhibition favors CRISPR/Cas9 gene correction over knock-out
Published : 10/29/2025Authors: Wilbie D, Eising S, Amo-Addae V, Walther J, Bosman E, et al. Source: PLOS ONE 20(9): e0332617. They screened a library of oncological drug compounds to steer the DNA repair...
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Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells
Published : 10/15/2025Authors: M. M. Trines, D. Hoorn, S. R. Hofstraat, et al. Source: Adv. Mater. (2025). They designed a series of polyvalent ionizable cationic dendrimers and incorporated...
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The adaptor SKT interacts with PSD-95 and SHANK3 and affects synaptic functions
Published : 10/08/2025Authors: Morellato, Alessandro et al. Source: Cell Reports. They identified the adaptor protein SKT as a crucial component of the postsynaptic density (PSD) network...
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Inhibition of convertase SKI-1 prevents blood vessel alteration after stroke
Published : 10/01/2025Authors: Shabanzadeh, A.P., Ringuette, D., Syonov, M. et al. Source: Nat Cardiovasc Res. They have demonstrated that inhibiting the extracellular protease SKI-1...
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Cholesterol in mRNA-Lipid Nanoparticles can be Replaced with the Synthetic MMG-1
Published : 09/17/2025Authors: A. G. Lokras, et al. Source: Adv. Funct. Mater. (2025). They demonstrated that replacing cholesterol in mRNA-Lipid Nanoparticles (LNPs)...
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Uukuniemi virus infection remodels the RNA-binding proteome in tick cells
Published : 09/10/2025Authors: Wilson A, Kamel W, Davies K, De Laurent ZR, Arif R, et al. Source: PLOS Pathogens. They conducted the first comprehensive analysis of protein-RNA interactions...
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Protocadherin γC4 Promotes Neuronal Survival in the Mouse Retina
Published : 09/03/2025Authors: McLeod, C.M., Lanthier, H.G., Nitschke, G.R. et al. Source: Mol Neurobiol (2025). They investigated the complex regulation of developmental neuronal apoptosis...