Blog
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Systematic Evaluation of GAPs and GEFs Identifies a Targetable Dependency
Published : 01/07/2026Authors: Pu Zhang, Zhendong Cao et al. Source: Cancer Discov. They utilized unbiased CRISPR-based functional genomics screens in Acute Myeloid Leukemia (AML)...
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Meningococci drive host membrane tubulation to recruit their signaling receptors
Published : 12/31/2025Authors: Laurent-Granger, A., Sollier, K., Saubamea, B. et al. Source: Nat Commun. They uncovered a crucial survival strategy utilized by Neisseria meningitidis...
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RNA innate immunity constitutes a barrier for interspecies chimerism
Published : 12/17/2025Authors: Hu, Yingying et al. Source: Cell. They uncovered a crucial barrier to generating interspecies chimeras: the competitive elimination of human pluripotent stem cells...
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Lymphoid gene expression supports neuroprotective microglia function
Published : 12/10/2025Authors: Ayata, P. et al. Source: Nature. They discovered that the protective function of microglia, the brain’s innate immune cells, against Alzheimer’s disease...
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Multiple LDLR family members act as entry receptors for yellow fever virus
Published : 11/26/2025Authors: Chong, Z., Hui, S., Qiu, X. et al. Source: Nature (2025). "They conducted a pivotal study using a CRISPR–Cas9 screen to clarify the long-unanswered
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ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration
Published : 11/12/2025Authors: Qiwang Xiang et al. Source: Sci. Adv. They identified the E3 ubiquitin-protein ligase ITCH as a critical driver of Golgi fragmentation, a recognized...
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Human CD4 T cells are functional targets for LNP-based mRNA vaccines
Published : 11/06/2025Authors: Kim SC, et al. Source: mBio. They discovered that CD4 T cells are an unexpected and dominant target for lipid nanoparticle (LNP) transfection...
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Aurora Kinase A inhibition favors CRISPR/Cas9 gene correction over knock-out
Published : 10/29/2025Authors: Wilbie D, Eising S, Amo-Addae V, Walther J, Bosman E, et al. Source: PLOS ONE 20(9): e0332617. They screened a library of oncological drug compounds to steer the DNA repair...