Blog
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Geneformer-guided multiomics identifies Pbx1 as a network hub of HSC aging
Published : 09/16/2026Authors: Hiroshi Kobayashi et al. Source: Science Advances. They integrated deep learning foundation models with transcriptomic and epigenetic profiling to...
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Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia
Published : 09/02/2026Authors: Medina-Guzmán, R., et al. Source: Cell Death Dis. They showed that basal caspase-3 activity regulates RNA splicing in microglia, and its deficiency in a Parkinson's disease...
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How Magnetofection unlocks high-efficiency CRISPR Genome Editing
Published : 08/25/2026Paper from: Go I, Lee SH. Front Genome Ed. A controlled, head-to-head benchmark of PolyMag Neo magnetofection against lipofection across Cas9, Cas12, prime editing and RNP delivery.
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HIV-1-specific CAR-T cell activity enhanced by IL-15 and TGF-β modulation
Published : 08/19/2026Authors: Lamcaj S et al. Source: Journal of Virology. They demonstrated that HCW9218, a bifunctional immunomodulatory protein composed of TGF-βRII...
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Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery
Published : 08/05/2026Authors: Mathieu Repellin et al. Source: Journal of Controlled Release. They demonstrated that muscle cells are not just passive recipients but vital antigen-producing...
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Distinct antigen presentation drives potent T cell immunity in mRNA-LNP vaccines
Published : 07/29/2026Authors: Ryunosuke Muro et al. Source: Science Advances. They identified an unconventional antigen presentation pathway driven by migratory type 2...
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Development of a gene-activated matrix for enhanced AAV gene delivery in vitro
Published : 07/21/2026New publication that concretizes the work carried out on the development of AAVBlast during the EU-funded SBR grant.
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Inhibition of pathogenic tau signaling by novel small molecules
Published : 07/01/2026Authors: Nowar R et al. Source: Front. Pharmacol. They identified a series of novel small-molecule inhibitors that target a specific toxic region of the tau protein...