Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia

BLOG > Publications & Citations > Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia

Authors: Medina-Guzmán, R., Bahatyrevich-Kharitonik, B., St-Pierre, MK. et al.

Source: Cell Death Dis (2026).

We're thrilled to share insights from a recent study entitled "Caspase-3 regulates RNA splicing and mitochondrial dynamics in microglia during Parkinson's disease" published in Cell Death & Disease by Rafael Medina-Guzmán et al.

They showed that basal caspase-3 activity regulates RNA splicing in microglia, and its deficiency in a Parkinson's disease model leads to splicing dysregulation, double-stranded RNA accumulation, type I interferon response, impaired mitochondrial respiration, and reduced ATP production. These findings uncover a non-apoptotic, homeostatic role for basal caspase-3 activity in microglia, positioning caspase-3 as a critical regulator of microglial function in health and disease.

Congratulations to all the authors on this excellent article!

Glial-Mag was used to to transfect BV2 murine microglial cells with siRNA via magnetofection.

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