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BLOG > Publications & Citations > Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype
Authors: Cheray, M., Posada-Pérez, M., Fragkopoulou, A. et al.
Source: Cell Death Differ (2026).
We're delighted to share insights from a recent study entitled "Glioma-induced DNMT3A reduction in microglia promotes an anti-tumoral phenotype" published in Cell Death & Differentiation by Cheray, M., Posada-Pérez, M., Fragkopoulou, A. et al.
Congratulations to all the authors on this excellent article!
They discovered that a transient reduction in DNA methylation, specifically involving the enzyme DNMT3A, can reprogram microglia into a reactive state that actively combats tumor growth. This research highlights microglial DNMT3A as a promising therapeutic target for treating aggressive brain neoplasms like glioblastoma.
Glial-Mag was used to perform efficient siRNA transfection in primary microglia, enabling the gene silencing experiments needed to validate the anti-tumoral functions of these cells.
Read the article See Glial-Mag
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