Blog
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SMURF1 and SMURF2 target GLI1 for ubiquitination and degradation
Published : 01/08/2025Authors: Fabio Bordin, Gloria Terriaca et al. Source: Cell Death Discovery. The transcription factor GLI1 is the main and final effector of the Hedgehog...
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Periodic ER-PM junctions enable long-range Ca2+ signaling
Published : 01/03/2025Authors: Benedetti, Lorena et al. Source: Cell. "Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms...
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Challenges in AAV-Based Retinal Gene Therapies
Published : 12/18/2024Authors: Siontas, Olivier and Ahn, Seungkuk. Source: Journal of Clinical Medicine. "Retinal diseases, leading to various visual impairments and blindness,...
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Anti-SARS-CoV-2 serology and neutralizing antibodies against Omicron variants
Published : 12/10/2024Authors: Dépéry, Léa et al. Source: Microbiology Spectrum. "Neutralizing antibody titers and binding antibody levels are considered correlates...
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New insights into PPP2R2B variants in neurodevelopmental syndrome
Published : 12/05/2024Authors: Priyanka Sandal, Chian Ju Jong et al. Source: Human Molecular Genetics, 2024. "The heterotrimeric protein phosphatase 2A (PP2A) complex catalyzes...
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Modeling memory B cell responses on an organ chip to assess mRNA vaccine boosts
Published : 09/11/2024Authors: Raphaël Jeger-Madiot et al. Source: J Exp Med. "Predicting the immunogenicity of candidate vaccines in humans remains a challenge...
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Gene therapy improves outcomes in a mouse model of multiple sulfatase deficiency
Published : 04/08/2024Authors: Pham, Vi et al. Source: Molecular Therapy. "Multiple sulfatase deficiency (MSD) is a severe, lysosomal storage disorder caused by pathogenic...
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Phenotypic profiling of solute carriers characterizes serine transport in cancer
Published : 02/01/2024Authors: Papalazarou, V., Newman, A.C., Huerta-Uribe, A. et al. Source: Nature Metabolism. "Serine is a vital amino acid in tumorigenesis. While cells can perform...