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17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation

BLOG > Publications & Citations > 17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation

mRNA-LNP vaccine

Authors: Iemitsu, Keigo et al.

Source: Journal of Lipid Research, Volume 67, Issue 1, 100956.

We're delighted to share insights from a recent study entitled "17,18-epoxyeicosatetraenoic acid ameliorates mRNA-LNP–induced local inflammation by inhibiting neutrophil infiltration" published in Journal of Lipid Research by Keigo Iemitsu et al.

Congratulations to all the authors on this excellent article!

They demonstrated that lipid nanoparticles (LNPs), the crucial delivery platform for mRNA vaccines, induce local inflammatory side effects such as pain and swelling, primarily mediated by neutrophil infiltration at the injection site. By co-injecting the omega-3 fatty acid metabolite 17,18-EpETE, the researchers significantly reduced local swelling and inflammation through G protein–coupled receptor 40 (GPR40) activation. Critically, this anti-inflammatory approach did not impair the desired antigen-specific antibody production elicited by the mRNA-LNP vaccination. This finding offers a promising strategy to enhance the safety profile of next-generation nucleic acid therapeutics.

Our empty LNPs (eLNPs) and OVA mRNA-LNPs were used in this pioneering study to investigate LNP-induced inflammatory responses.

Read the article See Lipid Nanoparticles (LNPs)

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