Blog
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A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies
Published : 07/30/2025Authors: Xun Chen et al. Source: Sci. Adv. Focusing on the evolutionarily young LTR subfamilies known as MER11A/B/C, they revealed the presence of four “new subfamilies,”...
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Live-cell magnetic manipulation of endosomes’ effect on actin protrusions
Published : 07/23/2025Authors: Jakub Gemperle et al. Source: Sci. Adv. Scientists utilized an innovative magnetogenetic approach to precisely control Rab25 endosomes,...
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Aberrant phase separation of two PKA RIβ neurological disorder mutants
Published : 07/16/2025Authors: Pool, Emily H. et al. Source: Cell Reports. "Spatiotemporal regulation of key-node signaling molecules, such as 3′,5′-cyclic adenosine monophosphate...
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BCL2 drives castration resistance in castration-sensitive prostate cancer
Published : 07/10/2025Authors: Hirani, Rahim et al. Source: Cell Reports. "Progression following androgen-deprivation therapy (ADT) and the development of castration resistance...
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Lipid Nanoparticle Development for Bivalent mRNA Vaccine
Published : 06/25/2025Authors: Jiin Felgner et al. Source: npj Vaccines. "mRNA vaccines represent a promising alternative to conventional vaccines, as demonstrated by the rapid deployment of mRNA vaccines...
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T cell receptor mimic CAR T cells targeting cathepsin G signal peptide
Published : 06/18/2025Authors: Yan, J. et al. Source: Leukemia. "There has been a been a paucity of immunotherapy targets in myeloid malignancies. We identified the HLA-A2 (A2)...
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Impact of pre-existing anti-polyethylene glycol (PEG) IgM on biodistribution
Published : 06/04/2025Authors: Shunji Abe et al. Source: Journal of Controlled Release. "With the approval of mRNA vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), lipid nanoparticles (LNP)...
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Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction
Published : 05/09/2025Authors: Xiuhong Ye et al. Source: Adv. Sci. 2025. "Antisense oligonucleotide (ASO) therapy holds promise in gene therapy but faces challenges due to poor delivery efficiency...