Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery

BLOG > Publications & Citations > Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery

Authors: Mathieu Repellin et al.

Source: Journal of Controlled Release, Volume 397, 2026, 115128, ISSN 0168-3659.

We're delighted to share insights from a recent study entitled "Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery and efficacy" published in Journal of Controlled Release by Mathieu Repellin et al.

They demonstrated that muscle cells are not just passive recipients but vital antigen-producing reservoirs that drive robust adaptive immunity. By utilizing a specialized lipid-polymer hybrid nanosystem, the researchers achieved high transfection efficiency in myofibers, leading to potent humoral and cellular immune responses while maintaining a safe, localized distribution.

Congratulations to all the authors on this excellent article!

mRNAs (encoding eGFP, Cre, and OVA) were used to track delivery pathways, evaluate muscle cell transfection, and confirm the induction of successful immunization.

Read the paper mRNA Catalog

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