BLOG > Publications & Citations > CD8+ T-cell response in the lower airways during acute influenza infection
Authors: Adam Saidu et al.
Source: The Journal of Immunology, Volume 215, Issue 5, May 2026.
We're delighted to share insights from a recent study entitled "Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection" published in The Journal of Immunology by Adam Saidu et al.
Congratulations to all the authors on this excellent article!
They demonstrated that influenza-specific CD8+ T cells in the lower airways are highly expanded during acute infection, targeting conserved viral epitopes with a unique tissue-resident phenotype.
Their finding provide critical insights into how the human immune system could controls respiratory viral infections.
ViroMag was used to facilitate the efficient retroviral transduction of both primary human CD8+ T cells and Jurkat reporter cells, which was essential for the successful reverse epitope mapping of the discovered T-cell receptors.
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