BLOG > mRNA & LNP > Introduction to the new DIY Lipid Nanoparticles (LNP) Products
Summary of key informations
What are LNPs?
Definition and operation of LNPs
Lipid Nanoparticles (LNPs) are nanoscopic structures composed of lipids. They are used to encapsulate and deliver therapeutic molecules into the body. LNPs can transport various types of molecules, including nucleic acids such as mRNA and DNA. This makes them particularly useful in gene therapies and drug delivery.
LNPs act like tiny vehicles transporting their precious cargo – therapeutic molecules – throughout the body. They navigate through the bloodstream, avoiding obstacles and dangers, until they reach their destination: the target cells. Once there, they deliver their cargo, enabling therapeutic molecules to exert their effects.
LNPs represent the most effective and safe delivery systems for the translational success of nucleic acid drugs. LNPs are lipidic spherical vesicles formed by a combination of four main components: an ionizable cationic lipid, a helper phospholipid, cholesterol & a pegylated lipid, each having distinct functions (Fig.1). LNPs not only protect RNA from degradation, but also facilitate intracellular uptake and thus potentiate its efficacy. LNP/RNA systems self-assemble via electrostatic interactions between negatively charged RNA and ionizable cationic lipids.
Fig.1. Schematic representation of LNPs-mRNA
Products overview
OZ Biosciences has developed a range of four different LNPs DIY, tailored to your needs.
NanOZ LNP-DIY (SS1)
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NanoZ-LNP-DIYSS1 is a ready-to-use lipid mixture designed for formulating LNP-mRNA, LNP-DNA, LNP-saRNA, or LNP-sgRNA. It provides an encapsulation efficiency of 80-96% under optimized conditions. Ideal for those seeking to encapsulate nucleic acids for therapeutic applications. The NanoZ-LNP-DIYSS1 is more than just a lipid mixture. It is a turnkey solution for LNP formulation. With it, you don't need to be an expert in nanotechnology to create your own LNPs. You can simply mix your nucleic acids with NanoZ-LNP-DIYSS1, and there you go – you have your own ready-to-use LNPs. |
NanOZ LNP-DIY (105S)
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NanoZ-LNP-DIY105S is a ready-to-use lipid mixture designed for formulating LNP-siRNA, LNP-miRNA, or LNP-Oligonucleotide. It offers an encapsulation efficiency of 80-96% under optimized conditions. Perfect for those looking to encapsulate small RNAs for gene silencing applications. The NanoZ-LNP-DIY105S is an ideal solution for those working with small RNAs. Whether you aim to downregulate the expression of a specific gene with siRNAs, finely regulate gene expression with miRNAs, the NanoZ-LNP-DIY105S has what you need. |
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NanOZ LNP-DIY (SM102)
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NanoZ-LNP-DIY-SM102 is a ready-to-use lipid mixture designed for formulating LNP-mRNA. It provides an encapsulation efficiency of 80-96% under optimized conditions. Ideal for those looking to encapsulate mRNA for therapeutic applications.
The NanoZ-LNP-DIY-SM102 is your ally for mRNA-based gene therapy. Whether you aim to express a therapeutic gene in target cells or induce an immune response against a specific antigen, the NanoZ-LNP-DIY-SM102 can help you achieve your goals. |
NanOZ LNP-DIY (FP105)
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NanoZ-LNP-DIYFP105 is a ready-to-use lipid mixture designed for formulating LNP-mRNA. It offers an encapsulation efficiency of 80-96% under optimized conditions. Perfect for those looking to encapsulate mRNA for therapeutic applications. The NanoZ-LNP-DIYFP105 is a versatile solution for LNP-mRNA formulation. Whether you aim to express a therapeutic gene, induce an immune response, or study gene expression, the NanoZ-LNP-DIYFP105 is the product you need. |
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Products comparison
Comparative table of products
Here is a comparative table of the four products:
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Products |
Usage |
Encapsulation Efficiency |
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NanoZ-LNP-DIYSS1 |
LNP-mRNA, LNP-DNA, LNP-saRNA, LNP-sgRNA |
80-96% |
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NanoZ-LNP-DIYFP116 |
LNP-siRNA, LNP-miRNA, LNP-ASO |
80-96% |
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NanoZ-LNP-DIY-SM102 |
LNP-mRNA |
80-96% |
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NanoZ-LNP-DIYFP105 |
LNP-mRNA |
80-96% |
How to choose the right product for your needs
To choose the right product, determine the type of molecule you want to encapsulate. If you are working with mRNA, NanOZ LNP-DIY (SS1), NanOZ LNP-DIY (SM102), or NanOZ LNP-DIY (FP105) would be suitable. If you are working with small RNAs like siRNA, miRNA, or ASO, NanOZ LNP-DIY (FP116) would be the best choice.
It is also important to consider other factors, such as cost, ease of use, and compatibility with your existing experimental protocols. Feel free to contact us if you need assistance in choosing the right product.
To conclude, LNPs are a significant technology in biosciences, and these new products offer a variety of options to meet different user needs. Feel free to contact us for more information or to place an order. We are here to help you make the best choice for your biosciences needs. So, don't hesitate, take the step, and discover the power of DIY LNPs!
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