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NanOZ Fluo LNP-DiO
Ready-to-use DiO-labeled LNPs for in vitro cellular and subcellular distribution and in vivo imaging..
Concentration: 1 mole % of DiO in 4.5 mM of LNPs in PBS with 10 % sucrose.
LNPs represent one of the most effective and safe delivery systems for the translational success of nucleic acid drugs. LNPs are lipidic spherical vesicles formed by a combination of four main components: an ionizable cationic lipid, a helper phospholipid, cholesterol & a pegylated lipid, each having distinct functions. LNPs not only protect RNA from degradation, but also facilitate intracellular uptake and thus potentiate its efficacy.
NanOZ Fluo LNP-DiO (Fig.1) is designed for the effective monitoring and imaging of intracellular trafficking and biodistribution of LNPs in vitro and in vivo respectively.
NanOZ Fluo LNP-DiO contains a lipophilic carbocyanine dye DiO having an excitation max. at 487 nm, and emission max. at 501 nm.
Kit contents:
LFR11000: 1mL (4*250μL) of LNP-DiR, (4.5 mM) having composition as described in table below:
Lipid mix components | Molecular weight | Molar ratio | mM |
FP105 | 731.2 | 50 | 2.29 |
DSPC |
790.17 | 9 | 0.41 |
Cholesterol | 386.65 | 38.5 | 1.76 |
DMG-PEG 2000 | 2509.2 | 1.5 | 0.07 |
DiR | 1013 | 1 | 0.05 |
Total | 100 | 4.5 |
Storage
NanOZ Fluo LNP-DiR must be stored at -80°C. We recommend to minimize freeze-thaw cycles to preserve LNPs integrity.
Catalog number | Unit Size | Price excl tax | Quantity / Buy |
LFO11000 |
1ml
|
$1,025.00
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