const consentListeners = []; window.ConsentListener = (callback) => { consentListeners.push(callback); }; const onConsentChange = (consent) => { consentListeners.forEach((callback) => { callback(consent); }); };

A multichaperone condensate enhances protein folding in the endoplasmic reticulu

BLOG > Publications & Citations > A multichaperone condensate enhances protein folding in the endoplasmic reticulum

Helix IN transfection reagent

Authors: Leder, A., Mas, G., Szentgyörgyi, V. et al.

Source: Nat Cell Biol (2025).

We are thrilled to share insights from a genuine study entitled "A multichaperone condensate enhances protein folding in the endoplasmic reticulum" published in Nature Cell Biology by Anna Leder et al.

They discovered that the ER protein PDIA6 forms dynamic, calcium-dependent multichaperone condensates, acting as "folding factories" that actively enhance protein folding and prevent misfolding. This crucial self-organized structure significantly impacts protein processing (e.g., proinsulin) and maintains cell viability, revealing a new layer of organization in ER proteostasis.

Congratulations to all the authors on this excellent article!

Our Helix-IN transfection reagent was used to facilitate transient cell transfections in various cell lines (HeLa, HEK293A, U2OS, INS-1) and to generate the stable Halo-tagged PDIA6 HeLa cell line, as well as for CRISPR-Cas9-mediated gene knockout attempts, which further confirmed PDIA6's essential role.

Read the article Check Helix-IN

Related publications

dna transfection

Aberrant phase separation of two PKA RIβ neurological disorder mutants

Authors: Pool, Emily H. et al. Source: Cell Reports. "Spatiotemporal regulation of key-node signaling molecules, such as 3′,5′-cyclic adenosine monophosphate...
Read more
dna transfection reagent

Discovery of a sushi domain-containing protein 2-positive phenotype

Authors: Bartkowiak, K. et al. Source: Nature Scientific Reports. "Cell lines derived from circulating tumor cells (CTCs) in the blood provide important biological...
Read more
Helix IN transfection reagent

Anti-SARS-CoV-2 serology and neutralizing antibodies against Omicron variants

Authors: Dépéry, Léa et al. Source: Microbiology Spectrum. "Neutralizing antibody titers and binding antibody levels are considered correlates...
Read more