NanOZ LNP-DIY(FP105)
Ready-to-use dried lipid mix at the total lipid concentration of 25 mM when reconstituted in 1mL Ethanol, for LNP-mRNA formulation.
LNPs represent the most effective and safe delivery systems for the translational success of nucleic acid drugs. LNPs are lipidic spherical vesicles formed by a combination of four main components: an ionizable cationic lipid, a helper phospholipid, cholesterol & a pegylated lipid, each having distinct functions. LNPs not only protect RNA from degradation, but also facilitate intracellular uptake and thus potentiate its efficacy. LNP/RNA systems self-assemble via electrostatic interactions between negatively charged RNA and ionizable cationic lipids.
NanOZ LNP-DIY(FP105) is designed for the development of LNP by customer at their ease by using different formulation methods at different N/P ratio.
With our NanOZ LNP-DIY(FP105) system, customers can produce themselves a monodisperse LNP encapsulating mRNA within the size range of 50 nm to 200 nm through microfluidic/ impingement jets mixing (IJM)/T-junction mixing technology with an encapsulation efficiency of 80-96 % under optimized conditions. One vial of 25 mM will allow the production of 4 formulations of 1 mL with a concentration of 100µg/mL of mRNA.
Kit contents:
- LDIY105: Dried 25 mM lipid mix (50 mol% FP105, 38.5 mol% cholesterol, 10 mol% DSPC, and 1.5 mol% DMG-PEG2000)
Application:
- For In Vitro: variety of cells (RAW 264.7, THP-1, PANC-1, HeLa) ; for T cells -> please contact us for optimized solutions
- For In Vivo: suitable for I.P, S.C, I.M, etc... ; for I.V -> please contact us for optimized solutions
Storage:
NanOZ LNP-DIY(SM102) must be stored at -20°C as a dried film and at -80°C as ethanolic solution. Dried lipidic film can be stored for 6 months whereas ethanolic solution must be used within one month.
Shipping Conditions: Dry Ice.
Dry ice fee included in shipping cost.
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Catalog number | Unit Size | Price excl tax | Quantity / Buy |
LDIY105 |
25 mM
|
$600.00
|
|
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