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Inhibition of convertase SKI-1 prevents blood vessel alteration after stroke

BLOG > Publications & Citations > Inhibition of convertase SKI-1 prevents blood vessel alteration after stroke

293 transfection

Authors: Shabanzadeh, A.P., Ringuette, D., Syonov, M. et al.

Source: Nat Cardiovasc Res 4, 1094–1113 (2025).

We're delighted to share insights from a groundbreaking study entitled "Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke" published in Nature Cardiovascular Research by Alireza P. Shabanzadeh et al.

They have demonstrated that inhibiting the extracellular protease SKI-1 with PF-429242 can restore blood vessel integrity and promote functional recovery after stroke in both large and small animal models. This study reveals a critical mechanism where SKI-1's cleavage of the protein RGMa is necessary for RGMa to interact with Neogenin and compromise vessel integrity. By either preventing this RGMa cleavage or deleting Neogenin on endothelial cells, the researchers observed a significant reduction in blood vessel dysfunction, enhanced tissue preservation, and restored brain function after stroke. This work identifies a much-needed therapeutic strategy that offers hope for better stroke recovery outcomes.

Congratulations to all the authors on this excellent article!

Our HYPE-293 was utilized in this research for efficient protein production in HEK293F cells, a critical step in understanding RGMa cleavage and its inhibition.

Read the article See HYPE-293

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