LNP Stem Cells
mRNA encoding eGFP formulated in Lipid Nanoparticles designed for stem cell transfection.
Lipid Nanoparticles (LNPs) represent the most effective and safe delivery systems for nucleic acid delivery. Stem cells are among the most challenging cell types to transfect using conventional approaches, due to their unique biological properties and their sensitivity to cytotoxic stress.
NanOZ-LNP Stem is a proprietary lipid formulation optimized for multipotent and pluripotent stem cells, that protects mRNA from degradation and facilitate intracellular uptake.
Our delivery systems are produced through microfluidic technology resulting in monodisperse NanOZ LNP-mRNA with narrow size distribution and high encapsulation efficiency (>80%).
Main advantages over standard transfection methods:
- High transfection efficiency across a wide range of stem cells from cell line to primary stem cells.
- Minimized cytotoxicity through ionizable lipid biodegradability.
- Cell phenotype and differentiation preserved.
- No specific transfection buffer required.
- Ready-to-use formulation.
Concentration: 0.1 mg/mL mRNA in LNPs in PBS with 10% sucrose.
Kit content:
- LNPSC0500: 0,5mL (2*250μL) of LNP-mRNA, (100μg/mL of 5moU GFP mRNA).
- LNPSC1000: 1mL (4*250μL) of LNP-mRNA, (100μg/mL of 5moU GFP mRNA).
- LNPSC5000: 5mL (20*250μL) of LNP-mRNA, (100μg/mL of 5moU GFP mRNA).
Quality Control:
| Items | Specification | Standard QC | Superior Grade QC* |
|---|---|---|---|
| Identity | Size | ✓ | ✓ |
| Charge | ✓ | ✓ | |
| Content | Encapsulation efficiency | ✓ | ✓ |
| RNA concentration | ✓ | ✓ | |
| Safety | Sterility | ✓ | ✓ |
| Endotoxin | ✓ | ||
| Mycoplasma detection | ✓ | ||
| Characterization | Lipid content | ✓ |
* our catalog LNP undergo the standard QC, Superior Grade QC can be performed as an additional prestation. Contact us to get a quote.
Storage: -80°C. We recommend to minimize freeze-thaw cycles to preserve LNPs integrity.
Shipping Conditions: Dry Ice (dry ice fee included in shipping cost).
| Catalog number | Unit Size | Price excl tax | Quantity / Buy |
| LNPSC0500 |
0,5mL (2*250µL) of LNP-mRNA GFP
|
$750.00
|
|
| LNPSC1000 |
1mL (4*250µL) of LNP-mRNA GFP
|
$1,319.00
|
|
| LNPSC5000 |
5mL (20*250µL) of LNP-mRNA GFP
|
$5,063.00
|
|
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