Small-Molecule-Mediated Depletion of the DYRK1B Protein Scaffold

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Authors: Miriam Ems, et al.

Source: ACS Pharmacol. Transl. Sci. (2026) 9 (9): 2419–2425.

We're thrilled to share insights from a new study entitled "Small-Molecule-Mediated Depletion of the Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1B (DYRK1B) Protein Scaffold" published in ACS Pharmacology & Translational Science by Miriam Ems et al.

They identified LCTB-92, a small molecule from the leucettinib class of DYRK inhibitors, that not only suppresses DYRK1B kinase activity but also promotes selective ablation of the DYRK1B protein while sparing the closely related paralog DYRK1A. This establishes a foundation for the development of agents capable of targeting both catalytic-dependent and catalytic-independent DYRK1B functions.

Congratulations to all the authors on this excellent article!

Helix-IN transfection reagent was used to transfect Patu cells with the EF-DYRK1B plasmid for the rescue of DYRK1B knockout cells.

Read the article Access Helix-IN

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