AMBRA1 enhances Sonic Hedgehog signaling in cerebellum and medulloblastoma

BLOG > Publications & Citations > AMBRA1 enhances Sonic Hedgehog signaling in cerebellum and medulloblastoma

Authors: Irene Basili et al.

Source: Developmental Cell, 2026, ISSN 1534-5807.

We're delighted to share insights from a recent study entitled "AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma" published in Developmental Cell by Irene Basili et al:

Congratulations to all the authors on this excellent article!

They identified AMBRA1 as a key-tumorigenic factor that drives the Sonic Hedgehog subtype of medulloblastoma. By Stabilizing the GLI1 protein and preventing its degradation, AMBRA1 sustains the signaling pathways necessary for tumor progression, offering a promising new therapeutic target for pediatric brain cancer.

DreamFect and DreamFect Gold transfection reagents were used to perform the essential molecular studies and genetic modulations described in this research.

Read the article DNA transfection reagents

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