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Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells

BLOG > Publications & Citations > Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells

mCherry mRNA

Authors: M. M. Trines, D. Hoorn, S. R. Hofstraat, et al.

Source: Adv. Mater. (2025): e04830.

We're delighted to share insights from a genuine study entitled "Dendrimers Improve Apolipoprotein Nanoparticle mRNA Delivery to Immune Cells" published in Advanced Materials by Mirre M. Trines et al.

They designed a series of polyvalent ionizable cationic dendrimers and incorporated them into apolipoprotein nanoparticles (aNPs) for efficient mRNA complexation and delivery. Their leading formulation successfully delivered mRNA to significantly more myeloid progenitor cells in the bone marrow of mice compared to nanoparticles containing a clinically approved ionizable lipid, resulting in higher protein expression.

Congratulations to all the authors on this excellent article!

Our mCherry mRNA was used as a reporter gene in their in vivo model to evaluate the functional delivery and expression efficiency of these novel dendrimer-based aNPs in immune cells.

Read the article mCherry mRNA

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