const consentListeners = []; window.ConsentListener = (callback) => { consentListeners.push(callback); }; const onConsentChange = (consent) => { consentListeners.forEach((callback) => { callback(consent); }); };

Live-cell magnetic manipulation of endosomes’ effect on actin protrusions

BLOG > Publications & Citations > Live-cell magnetic manipulation of endosomes’ effect on actin protrusions

CombiMag

Authors: Jakub Gemperle et al.

Source: Sci. Adv.11,eadu6361(2025).

We are delighted to share insights from a recent study entitled "Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration" published in Science Advances by Jakub Gemperle et al:

Scientists utilized an innovative magnetogenetic approach to precisely control Rab25 endosomes, demonstrating that their peripheral localization is sufficient to drive F-actin protrusion formation.... This addresses a key challenge in understanding whether Rab GTPases actively initiate cellular protrusions or merely deliver receptors56. The underlying mechanism involves Rab25 coordinating the positioning of FMNL1 and integrin β1 with Rho GTPase activation to promote invasive migration in 3D matrices.... Crucially, the initial CRISPR/Cas9-based gene editing to reactivate Rab25 expression in A2780 ovarian cancer cells was enabled by Magnetofection. Specifically, OZBiosciences' Combimag nanoparticles were vital for the efficient delivery of CRISPR/Cas9 ribonucleoproteins (RNPs) and single-stranded DNA donors, proving essential for establishing this powerful experimental system. This study truly showcases the causal effects of endosome positioning in cancer biology.

Congratulations to all authors for this great article.

Our CombiMag Transfection Reagent was used to transfect A2780 with RNP.

Read the article See our CombiMag 

Related publications

combimag

Magnetic-Guided Delivery of Antisense Oligonucleotides for Targeted Transduction

Authors: Xiuhong Ye et al. Source: Adv. Sci. 2025. "Antisense oligonucleotide (ASO) therapy holds promise in gene therapy but faces challenges due to...
Read more
CombiMag

TREK-1 in regulating adipocyte differentiation and lipid accumulation

Authors: Kim, A., Jung, S., Kim, Y. et al. Source: Cell Death Dis 16, 164 (2025). "K2P (two-pore domain potassium) channels, a diversified class...
Read more
Transfection reagent

Implantation of engineered adipocytes suppresses tumor progression

Authors: Nguyen, H.P., An, K., Ito, Y. et al. Source: Nature Biotechnology (2025). "Tumors exhibit an increased ability to obtain...
Read more