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New kit for the detection of Double-stranded RNA

BLOG > mRNA & LNP > New Kit for the detection of Double-stranded RNA

We are pleased to announce that we are launching a new kit for the detection of Double-stranded RNA.

Double-stranded RNA (dsRNA) emerges as a by-product during the in vitro transcription of mRNA. This byproduct possesses immunogenic properties within the human body, capable of provoking an immune response, consequently diminishing mRNA levels. This renders dsRNA a troublesome process impurity necessitating thorough elimination and stringent control of its residual presence.

To address this concern, the Double-stranded RNA (dsRNA) ELISA detection kit employs the experimental principles of a double-antibody sandwich enzyme-linked immunoassay (ELISA) for the quantification of residual dsRNA. The Kit can not only be used in the detection of regular dsRNAs, but also in detection of peudo UTP, N1-Me-peudo UTP and 5-OMe-UTP modified dsRNAs.

This kit serves a versatile purpose, enabling optimization of the biological product purification process, impurity control during intermediate stages, and release testing for final product assessment.

dsRNA quantification with the dsRNA ELISA Kit

Figure 1: dsRNA quantification with the dsRNA ELISA Kit in several mRNA with different nucleotide modifications produced by OZ Biosciences

See the dsRNA ELISA KitRead the protocol

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