LNP D-Lin-MC3-DMA
Lipid Nanoparticles with D-Lin-MC3-DMA ionizable lipid, available with siRNA targeting GFP, GAPDH or NT-Cy5.
LNP-siRNA are designed to not only protect siRNA from degradation but also facilitate intracellular uptake and thus potentiate its efficacy.
Our delivery systems are produced through microfluidic technology resulting in monodisperse LNP/siRNA with narrow size distribution and high encapsulation efficiency (>80%).
LNP MC3 are produced with the same ionizable lipid as the Onpattro (Patisiran) siRNA treatment against hereditary transthyretin amyloidosis. Currently, LNPs hold great potential in diverse pharmaceutical applications including oncology, immunotherapy, regenerative medicine or chronic diseases treatment.
Concentration: 400 nM siRNA in LNPs
Kit contents:
- LNP30500siRNA1: 0.5 mL (2*250 μL) of LNP/siRNA GFP.
- LNP31000siRNA1: 1 mL (4*250 μL) of LNP/siRNA GFP.
- LNP35000siRNA1: 5 mL (20*250 μL) of LNP/siRNA GFP.
- LNP30500siRNA2: 0.5 mL (2*250 μL) of LNP/siRNA GAPDH.
- LNP31000siRNA2: 1 mL (4*250 μL) of LNP/siRNA GAPDH.
- LNP35000siRNA2: 5 mL (20*250 μL) of LNP/siRNA GAPDH.
- LNP30500siRNA3: 0.5 mL (2*250 μL) of LNP/siRNA NT-Cy5.
- LNP31000siRNA3: 1 mL (4*250 μL) of LNP/siRNA NT-Cy5.
- LNP35000siRNA3: 5 mL (20*250 μL) of LNP/siRNA NT-Cy5.
Quality Control:
| Items | Specification | Standard QC | Superior Grade QC* |
|---|---|---|---|
| Identity | Size | ✓ | ✓ |
| Charge | ✓ | ✓ | |
| Content | Encapsulation efficiency | ✓ | ✓ |
| RNA concentration | ✓ | ✓ | |
| Safety | Sterility | ✓ | ✓ |
| Endotoxin | ✓ | ||
| Mycoplasma detection | ✓ | ||
| Characterization | Lipid content | ✓ |
* our catalog LNP undergo the standard QC, Superior Grade QC can be performed as an additional prestation. Contact us to get a quote.
Storage: LNP-siRNA must be stored at -80°C for long-term storage (6 months). We recommend to minimize freeze-thaw cycles to preserve LNPs integrity.
Shipping Conditions: Dry Ice. (Dry ice fee included in shipping cost.)
This product is manufactured "on demand", which means that no stock is produced, so the expected delivery time is 2 to 3 weeks.
| Catalog number | Unit Size | Price excl tax | Quantity / Buy |
| LNP30500siRNA1 |
0.5 mL (2*250 μL) of LNP/siRNA GFP
|
$690.00
|
|
| LNP31000siRNA1 |
1 mL (4*250 μL) of LNP/siRNA GFP
|
$1,200.00
|
|
| LNP35000siRNA1 |
5 mL (20*250 μL) of LNP/siRNA GFP
|
$2,000.00
|
|
| LNP30500siRNA2 |
0.5 mL (2*250 μL) of LNP/siRNA GAPDH
|
$690.00
|
|
| LNP31000siRNA2 |
1 mL (4*250 μL) of LNP/siRNA GAPDH
|
$1,200.00
|
|
| LNP35000siRNA2 |
5 mL (20*250 μL) of LNP/siRNA GAPDH
|
$2,000.00
|
|
| LNP30500siRNA3 |
0.5 mL (2*250 μL) of LNP/siRNA NT-Cy5
|
$690.00
|
|
| LNP31000siRNA3 |
1 mL (4*250 μL) of LNP/siRNA NT-Cy5
|
$1,200.00
|
|
| LNP35000siRNA3 |
5 mL (20*250 μL) of LNP/siRNA NT-Cy5
|
$2,000.00
|
|
Citation database
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