Spike SARS CoV-2 saRNA
Ready-to-use stabilized SPIKE SARS COV-2 saRNA (E484K; N501Y)
Spike SARS-CoV-2 saRNAs have been designed to produce high expression level of SPIKE SARS COV-2 (E484K; N501Y) protein with enhanced length of duration. saRNAs are produced by in vitro transcription. saRNAs are stabilized at the 5’ end by modified nucleotides capping (Cap1) and contain a poly(A) tail at the 3’ end. Sequences have been optimized to yield improved stability and performance.
Spike SARS-CoV-2 saRNAs are also available capped with ExploCap™ upon request.
Spike SARS-CoV-2 self-amplifying RNA has been constructed based on replicons of positive-sense ((+)-RNA) viruses (Venezuelan equine encephalitis Virus (VEEV)), where the coding sequence of the viral structural proteins is replaced with that of a gene of interest (GOI, here SPIKE SARS COV-2 (E484K; N501Y)), while retaining the coding sequences of non-structural proteins (nsPs), including the viral RNA-dependent RNA polymerase. Please note that OZB saRNAs encodes also for Puromycin Resistance Cassette, which does not alter the expression of the GOI but can be used for cell selection.
- #MRNA78 does not bear any additional nucleotide modifications.
- #MRNA79 is modified with 5-methyl-Cytidine (m5C) (100% replacement of Cytidine).
mRNA length: 12911 nt.
Size: 20µg, 100µg and 1mg
Storage: saRNAs must be stored at -80°C. We recommend to aliquot the RNA solution for a better storage and avoid freeze/thaw cycles.
For Bulk, please contact us : order@ozbiosciences.com
| Catalog number | Unit Size | Price excl tax | Quantity / Buy |
| MRNA78-20 |
20µg (unmodified)
|
$120.00
|
|
| MRNA78-100 |
100µg (unmodified)
|
$375.00
|
|
| MRNA78-1000 |
1mg (unmodified)
|
$1,975.00
|
|
| MRNA79-20 |
20µg (m5C)
|
$170.00
|
|
| MRNA79-100 |
100µg (m5C)
|
$400.00
|
|
| MRNA79-1000 |
1mg (m5C)
|
$2,075.00
|
|
Citation database
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